压力诱导的胰岛激活敏感预测酒精渴望和酒精使用在酒精使用障碍中的酒精使用
Patrick Bach1, Judith Zaiser2, Sina Zimmermann2
1Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim. Heidelberg University, Heidelberg, Germany; Feuerlein Center on Translational Addiction Medicine, University of Heidelberg, Heidelberg, Germany.
Biological psychiatry
|September 7, 2023
概括
心理社会压力增加了酒精暗示反应在左侧岛屿的个人与酒精使用障碍. 这种增强的大脑反应与增加的酒精渴望和使用有关,突出强调了压力在成中的作用.
科学领域:
- 神经科学是一个神经科学.
- 成研究研究成研究
- 精神病学是一个精神病学.
背景情况:
- 压力和酒精暗示是饮酒和酒精使用障碍 (AUD) 复发的重要触发因素.
- 在AUD中,压力和酒精线索之间的相互作用背后的神经生物学机制仍然不完全理解.
- 这项研究研究了心理社会压力对神经对酒精暗示和随后的成行为反应的影响.
研究的目的:
- 检查心理社会压力对AUD个体神经暗示反应性的影响.
- 为了研究压力诱导的神经变化,酒精渴望,皮质醇水平和酒精使用之间的联系.
- 阐明AUD中与压力相关的复发的神经生物学基础.
主要方法:
- 一项随机对照的神经成像研究,涉及91名AUD患者.
- 功能磁共振成像 (fMRI) 用于评估基线和压力或对照条件后的神经酒精暗示反应.
- 收集了皮质醇水平,酒精渴望和12个月的酒精使用数据.
主要成果:
- 与对照条件相比,心理社会压力显著增加了酒精暗示诱导的左前胰岛激活.
- 这种特定于压力和暗示的胰岛激活随着时间的推移而动态增加,并由更高的皮质醇水平预测.
- 线索诱导的胰岛激活与随访期间的酒精渴望和随后的酒精使用有积极的相关性.
结论:
- 在AUD患者中,心理社会压力使左侧胰岛的提示诱导激活变得敏感.
- 这种神经敏感化作为压力对酒精渴望和使用的影响的生物标志物.
- 研究结果表明,改变显著性归因和目标导向行为有助于AUD中压力诱导的复发.
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