乳酸和乳酸化:常规碳源的临床应用和人类疾病中的新型修饰
Zhimin Wang1, Dan Hao2, Shuiying Zhao1
1Division of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Molecular & cellular proteomics : MCP
|September 7, 2023
概括
乳酸盐是糖解的副产物,通过代谢和表观遗传变化在细胞身份中发挥着关键作用. 本综述探讨了乳酸盐的使用情况.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 代谢学 代谢学 代谢学
背景情况:
- 细胞代谢产生调节翻译后修饰的中间体.
- 乳酸盐是一种糖解产物,通过代谢重新连接和表观遗传学影响细胞身份.
- 乳酸衍生碳化合物链接糖解,乳酸代谢和乳酸化.
研究的目的:
- 为了审查乳酸衍生碳的代谢命运.
- 为人类疾病的研究和治疗策略提供见解.
- 讨论乳酸在糖解调节,临床成像和与疾病相关的修改中的作用.
主要方法:
- 关于代谢途径和蛋白质乳糖化的文献综述.
- 分析乳酸在细胞命运决定和疾病中的作用.
- 探索超极化乳酸信号和奥米克应用的临床翻译.
主要成果:
- 乳酸盐显著影响细胞身份和表观遗传修饰.
- 蛋白质乳糖化与各种人类疾病有关,包括癌症和神经系统疾病.
- 乳酸代谢为诊断成像和治疗干预提供了潜力.
结论:
- 乳酸是关键代谢物,在细胞功能和疾病中发挥着不同的作用.
- 了解乳酸的代谢命运和乳糖化对于开发新的治疗策略至关重要.
- 对乳酸代谢及其临床应用的进一步研究具有重大前景.
相关概念视频
Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
Overview of Lipid Metabolism
1.7K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.7K
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Long-term Potentiation
55.3K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.3K


