微针用于先进的眼部药物输送
Katie Glover1, Deepakkumar Mishra1, Shilpkala Gade1
1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK.
Advanced drug delivery reviews
|September 7, 2023
概括
眼部药物输送面临着低生物可用性和侵入性手术的挑战. 微针贴片提供一种最小侵入性,局部化的方法,用于持续向眼睛输送药物,改善患者的治疗结果和接受.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 局部眼滴在前段疾病中具有较低的生物可用性 (<5%).
- 眼内注射是侵入性的,对后部部位疾病的患者接受度很低.
- 目前的眼部药物输送方法需要频繁的输送,这凸显了持续,局部输送的未满足需求.
研究的目的:
- 审查用于眼部药物输送的微针系统.
- 讨论使用的微针类型和治疗方法.
- 识别眼科中微针技术临床转化所面临的挑战和机会.
主要方法:
- 对用于眼部药物输送的微针系统的文献综述.
- 分析微针类型,治疗应用和输送机制.
- 讨论临床翻译挑战和未来方向.
主要成果:
- 微针使局部和持续的药物输送到眼睛成为可能.
- 这种方法可以提高药物通过眼壁的透率,提高治疗效率.
- 微针提供了一个微侵袭性替代体内注射,可能增加患者的可接受性.
结论:
- 微针技术对推进眼部药物输送具有重大前景.
- 解决当前的挑战对于成功的临床翻译至关重要.
- 需要进一步的研究和开发来优化微针系统,以便广泛用于眼科.
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