慢性咳患者的严重程度尺度的全球印象:症状严重程度类别的验证和制定
Katherine Rhatigan1, Barnaby Hirons1, Harini Kesavan2
1Department of Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom; Centre for Human and Applied Physiological Sciences, King's College London, London, United Kingdom.
The journal of allergy and clinical immunology. In practice
|September 7, 2023
概括
患者全球严重程度印象 (PGI-S) 规模有效评估慢性咳 (CC) 的严重程度. 这种经过验证,可重复和响应的工具有助于临床医生和患者了解咳的影响.
科学领域:
- 肺部病理学 肺部病理学
- 临床评估 临床评估
- 患者报告的结果
背景情况:
- 慢性咳 (CC) 评估通常使用患者全球严重性印象 (PGI-S) 尺度.
- PGI-S是一个自我报告的,单项的分类规模,在CC评估中获得了引力.
研究的目的:
- 确定PGI-S尺度在CC患者中的有效性,可重复性和响应性.
- 使用PGI-S尺度与其他患者报告结果 (PRO) 工具一起定义离散的严重程度类别.
主要方法:
- 482名连续的CC患者完成了PGI-S,咳严重程度和急需咳的视觉模拟尺度 (VAS) 和莱斯特咳问卷 (LCQ).
- 评估了PGI-S的有效性,可重复性和响应性.
- 确定了PRO严重程度类别的值得分.
主要成果:
- PGI-S显示了与咳严重程度VAS (ρ=0.81),急于咳VAS (ρ=0.73) 和LCQ (ρ=-0.73) 的强烈关联.
- 在PGI-S尺度上观察到高重复性 (类内相关系数=0.85).
- 在参与者显示治疗反应时,PGI-S反应良好,并确定了严重咳的PRO值.
结论:
- PGI-S尺度是一种简单,有效,可重复和响应的工具,用于表征慢性咳的严重程度.
- 为VAS和LCQ提出的分类严重程度值为患者和临床医生提供了直观的解释.
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