针-电针对炎症性疼痛的机制
Qingxiang Zhang1, Mengmeng Zhou1, Mingzhu Huo1
1Research Center of Experimental Acupuncture Science, College of Acumox and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Molecular pain
|September 7, 2023
概括
电针 (EA) 为炎症条件提供有效的疼痛缓解. 这次审查详细介绍了EA的细节.
科学领域:
- 综合医学是一个整体的医学.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 针是一种传统的中国疗法,被世界卫生组织认可为治疗许多疾病,包括炎症性疼痛.
- 电针 (EA),将针与电疗法结合起来,在急性和慢性疼痛中表现出显著的止痛作用.
- 尽管广泛接受,但针缓解疼痛的确切机制仍然不完全理解.
研究的目的:
- 系统地审查和阐明针在治疗炎症性疼痛中的外周和中心机制.
- 巩固当前的研究成果,以指导未来的研究和治疗疼痛的临床应用.
主要方法:
- 关于和电治疗炎症性疼痛的最新研究的综合文献综述.
- 在外周 (免疫细胞,神经元,纯能通路,大麻素受体,阿片类) 和中枢神经系统水平 (TRPV1,谷氨酸,质细胞,GABAergic内神经元) 的机制分析.
主要成果:
- 针的外围机制涉及免疫细胞,神经元,纯能信号传递,离子通道,大麻素受体和内源性阿片类药物的调节.
- 中心机制包括对TRPV1,谷氨酸路,质细胞,GABAergic内神经元和各种信号分子的影响.
- EA表现出有希望的止痛效果,副作用最小,支持其全球接受.
结论:
- 针和EA通过外周和中枢神经系统的复杂相互作用产生镇痛作用.
- 对这些机制的进一步研究可以优化炎症性疼痛管理的临床应用.
- 这篇评论为推进针在治疗炎症性疼痛中的作用提供了基础.
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