磁力共振成像 (MRI) 肺动脉流量检测到肺血管病理在肺部疾病的前期
Friederike Häfner1,2,3, Alida Kindt4,3, Kathrin Strobl2
1Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
The European respiratory journal
|September 7, 2023
概括
先进的MRI检测到肺血管疾病 (PVD) 在早产婴儿与支气管肺功能障碍 (BPD). 肺动脉流量和心脏功能异常改善了PVD风险分层,有助于早期干预.
科学领域:
- 新生儿医学 新生儿医学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 肺血管疾病 (PVD) 是常见的早产婴儿与支气管肺功能障碍 (BPD),往往进展到肺高血压和影响死亡率.
- 早期检测和新生儿PVD风险分层对于及时干预和改善结果至关重要.
研究的目的:
- 用先进的磁共振成像 (MRI) 将肺动脉 (PA) 流量和心脏功能特征与BPD相关的PVD近期关联起来.
- 为了改善患有BPD的早产新生儿PVD风险分层.
主要方法:
- 预期招募早产婴儿 (<32周PMA) 有/没有BPD进行自发睡眠中的3TMRI.
- 进行了半手动的PA流量量测量 (相对照MRI) 和心脏功能评估 (膜MRI).
- 分析包括没有BPD (n=28),轻度BPD (n=35) 和中度/重度BPD (n=25) 的患者.
主要成果:
- 与BPD相关的PVD (AUC 0.88,灵敏度 0.80,特异性 0.81) 灵敏地检测到PA流动 (例如,增加净向前体积右/左比) 和心脏功能 (例如,减少平均相对面积变化) 的异常.
- 这些变化与增加的右心室后负载,PA中断缩放和心脏指数相关.
- PVD概率与BPD严重性指标如机械通风持续时间和氧气补充强烈相关.
结论:
- 由MRI衍生的PA流和心脏功能异常协同检测BPD相关的PVD.
- 这些发现推进了BPD早产新生儿风险调整的监测策略.
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