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[免疫检查点抑制剂对老年患者的安全性和有效性]

Léah Mailly-Giacchetti¹, Daniel Lopez-Trabada¹, Judith Feldman²

¹Department of Medical Oncology, Saint-Antoine Hospital, AP-HP, Paris, France.

Bulletin du cancer

|September 7, 2023

概括

接受免疫检查点抑制剂 (ICI) 的老年患者通常表现出令人放心的安全数据. 然而,整体健康状况下降是不良事件的关键因素,需要对老年患者进行评估,并对这一群体进行特定风险评分.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
老年病的医生老年病的医生

背景情况:

免疫检查点抑制剂 (ICI) 是标准的癌症治疗方法.
在ICI临床试验中,老年患者的代表性不足.
衰老会影响免疫系统功能 (免疫发生,发炎),影响ICI的安全性和有效性.

研究的目的:

审查ICI在老年患者中的安全数据.
为了确定ICI治疗的老年人不良事件的风险因素.
突出对老年人ICI使用的老年特异性评估和风险评分的需要.

主要方法:

对ICI临床试验的回顾性研究和子组分析的审查.
分析影响老年癌症患者治疗相关不良事件的因素.

主要成果:

在老年患者中,ICI的整体安全数据令人放心.
总体健康状况的恶化是不良事件的独立预测因素,无论年龄如何.
目前的风险评估得分并不特定于老年人群中的ICI.

结论:

在临床实践中,老年评估查测试是必要的.
需要在老年患者中开发ICI使用的特定风险评分.
将老年患者纳入临床试验对于生成相关数据至关重要.

关键词:

不良事件是不良事件.癌症癌症癌症癌症副作用副作用的意思年长的老人.免疫治疗是一种免疫疗法.免疫疗法是一种免疫疗法.在瘤医院的医生.有毒性有毒性有毒性有毒性

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