在北欧国家,软组织和骨肉瘤的生存率在50年内稳步改善
Filip Tichanek1, Asta Försti2, Otto Hemminki3
1Biomedical Center, Faculty of Medicine, Charles University Pilsen, 30605 Pilsen, Czech Republic; Institute of Pathological Physiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Cancer epidemiology
|September 7, 2023
概括
在北欧国家,软组织肉瘤 (STS) 和骨肉瘤 (BS) 的生存率在过去50年里稳步提高. 这些在肉瘤护理方面的进步凸显了对罕见癌症更好的诊断和治疗策略的影响.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肉瘤是一种影响软组织,骨和软骨的罕见癌症,表现出多种不同的亚型.
- 这些罕见恶性瘤的国际生存趋势尚未得到充分记录.
- 这项研究分析了丹麦,芬兰,挪威和瑞典软组织肉瘤 (STS) 和骨肉瘤 (BS) 的50年生存趋势.
研究的目的:
- 介绍和分析北欧国家软组织肉瘤 (STS) 和骨肉瘤 (BS) 的50年生存趋势.
- 为了确定生存率的特定国家和性别差异.
- 评估五十年来生存率的改善.
主要方法:
- 利用了来自NORDCAN数据库 (1971-2020) 的相对1年,5/1条件和5年生存数据.
- 估计生存率的年度变化.
- 在生存趋势中确定了重要的断点.
主要成果:
- 在2016-20年,STS的5年生存率在挪威男性 (74.6%) 和芬兰女性 (71.1%) 中最高.
- 对于骨肉瘤 (BS),瑞典男性 (72.0%) 和丹麦女性 (71.1%) 的生存率最高.
- 对于BS的生存率在男性中仍然低于STS,而在2016-20年,在女性中几乎相等. 对STS和BS的5年生存率有显著的50年改善,特别是在挪威男性和芬兰女性中.
结论:
- 50年来持续改善的生存率表明,瘤的诊断,治疗和患者护理方面取得了进展.
- 较高的早期死亡率 (10-15%在第一年内) 表明潜在的诊断延迟,强调需要为罕见的,侵袭性疾病组织患者途径.
- 早期诊断和进一步的治疗突破仍然是改善肉瘤结果的关键挑战.
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