量化系统分子网络在高海拔去适应过程中受到影响.
Subhojit Paul1, Shikha Jain1, Anamika Gangwar1
1Peptide & Proteomics Division, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Timarpur, New Delhi, 110054, India.
Scientific reports
|September 7, 2023
概括
从高海拔返回会导致脱适应综合征 (HADAS) 带有头痛等症状. 这项研究使用蛋白质信息学来揭示HADAS对脂质代谢,炎症和凝血的影响,提供治疗见解.
科学领域:
- 人类生理学 人类生理学
- 网络生物学 网络生物学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 高海拔适应和疾病得到了充分的研究.
- 高度去适应或去诱导及其相关症状的理解较少.
- 最近的研究发现"高海拔脱适应综合症" (HADAS) 有着多种不同的临床表现.
研究的目的:
- 在高度去适应过程中研究人类等离子体蛋白质组的计算奥米克和网络生物学.
- 从高空降落后分析血蛋白质组和通路的变化.
- 为治疗策略提供框架,以缓解HADAS症状.
主要方法:
- 人体血蛋白质组的定量蛋白质信息学和网络生物学分析.
- 使用STRING和IPA分析蛋白质网络和上游监管器.
- 研究的血蛋白质组变化从到达高度后的第7天到下降后的第180天.
主要成果:
- 脱诱导显著影响脂质代谢,炎症和天生的免疫系统.
- 凝血系统的通路也受到高度脱适应的影响.
- 确定了特定的蛋白质网络和参与HADAS的上游监管机构.
结论:
- 高度脱适应对关键生理系统有深远的影响.
- 对HADAS的治疗策略应该针对脂质代谢,炎症信号和凝血.
- 这项研究为管理脱适应提供了一个新的概念框架.
相关概念视频
01:24Factors Affecting Respiration
5.2K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
5.2K
01:18Positive and Negative Feedback Loops
19.4K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires maintaining an internal dynamic equilibrium:
19.4K
01:29Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
01:21Acute Respiratory Failure-II
269
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
269
01:37Hypothalamic-Pituitary Axis
60.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.4K
01:31Chemical Factors Affecting Respiration Centers
1.2K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
1.2K