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在人类造血干细胞中基和原始编辑的基因毒性影响

Martina Fiumara1,2, Samuele Ferrari3,4, Attya Omer-Javed1

  • 1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Nature biotechnology
|September 7, 2023
PubMed
概括

基和主要编辑器 (BEs和PE) 对精确的基因工程具有前景,但可能导致有害的细胞反应和基因毒性. 在临床应用之前需要进一步的研究.

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