通过辅助生殖技术怀孕的孩子的长期结果
Masanori Ono1, Naoaki Kuji2, Keiko Ueno2
1Department of Obstetrics and Gynecology, Tokyo Medical University, Shinjuku (Tokyo), Japan. masanori@tokyo-med.ac.jp.
Reproductive sciences (Thousand Oaks, Calif.)
|September 7, 2023
概括
辅助生殖技术 (ART) 的出生率正在上升. 长期研究表明,通过ART怀孕的儿童.
科学领域:
- 生殖医学 生殖医学
- 儿科发展 儿科发展
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,辅助生殖技术 (ART) 产生的数量正在增加,在2020年,日本有60,381名婴儿出生.
- 越来越多的人对人工智能治疗的兴趣,需要了解通过这些方法怀孕的儿童的长期结果.
- 现有的研究表明,与自然受孕的同龄人相比,ART受孕儿童的发育轨迹存在各种各样的发现.
研究的目的:
- 调查通过ART产生的儿童的长期身体和精神运动发展.
- 为了比较ART怀孕和自然怀孕的孩子之间的发育结果.
- 识别与受孕方法相关的儿童发展的潜在差异和促成因素.
主要方法:
- 观察性研究的系统审查和元分析.
- 收集有关身体生长参数和心理运动发展里程碑的数据.
- 在ART怀孕和自然怀孕队伍之间对发育数据的比较分析.
主要成果:
- 在长期的身体特征的ART怀孕的孩子通常与那些自然怀孕的孩子相比较.
- 一些研究表明,在学龄前通过ART怀孕的儿童中,生长差异较小.
- 没有观察到学业成绩或注意力缺陷多动症 (ADHD) 率的显著变化.
结论:
- 虽然在幼儿时期可能存在微小的生长变化,但ART孕育的儿童的长期身体和精神运动发育似乎与自然孕育的儿童相似.
- 观察到的差异可能归因于遗传或环境因素,而不是ART本身.
- 需要进一步的研究来确定任何发育差异的原因.
相关概念视频
In Vitro Fertilization
326
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
326
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Longitudinal Studies
186
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
186
Infertility in Males
295
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
295


