在患有多发性硬化症的不孕妇女中,辅助生殖技术和疾病管理
Maddalena Sparaco1, Luigi Carbone2, Doriana Landi3
1Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138, Naples, Italy.
CNS drugs
|September 7, 2023
概括
辅助生殖技术 (ART) 可能会增加患有多发性硬化症 (wMS) 的女性复发风险. 建议对ART进行稳定的疾病,并进行仔细监测和兼容的疾病修饰疗法 (DMT),以确保安全.
科学领域:
- 神经学 神经学
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 主要影响生育年龄的女性,不孕症管理和辅助生殖技术 (ART) 要求的比例不断增加.
- 性功能障碍,内分泌变化,自身免疫失衡和疾病修饰疗法 (DMT) 等因素可能会影响MS患者的生育能力.
研究的目的:
- 审查WMS中的ART数据,解决安全问题,并讨论不孕症治疗的临床考虑.
- 为神经科医生提供最新的建议,管理接受ART的wMS,旨在尽量减少手术后的疾病活动.
- 引导寻求生育治疗的WMS的管理,并确保与安全妊娠结果一起控制疾病.
主要方法:
- 对WMS中的ART现有数据的审查.
- 讨论与WMS中ART相关的临床方面和安全问题.
- 为神经病学家和临床医生制定最新的建议.
主要成果:
- 在WMS中,ART与复发率增加和磁共振成像 (MRI) 活动有关.
- 应考虑在稳定疾病的WMS中进行ART,以减少复发风险.
- 应该及早讨论生育问题,特别是在疾病活跃度较高的妇产产科医生中,考虑生育保存和DMT选择.
结论:
- 在ART前的评估应包括维生素D,甲状腺功能,感染查和生活方式改变.
- 对于卵巢刺激,可能更喜欢那多释放激素 (GnRH) 抗剂.
- 建议在ART后进行密切的临床和放射性监测,特别是在激素刺激或怀孕失败后.
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