吸烟,饮酒和杜普伊特伦病风险:孟德尔的随机化研究
Zifeng Wang1,2, Zhenyu Wang1, Zijian Yan3
1Department of Orthopedics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214000, China.
BMC medical genomics
|September 7, 2023
概括
这项研究发现,增加的酒精消费,以每周饮料来衡量,因果上增加了杜普伊特伦风险.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 医学研究 医学研究
背景情况:
- 吸烟,酒精和杜普伊特伦病 (Dupuytren's disease,DD) 之间的联系已知,但因果关系尚不清楚.
- 以前的研究已经承认了相关性,但明确的因果关系途径仍然难以捉摸.
- 研究遗传倾向可以帮助阐明因果关系.
研究的目的:
- 确定吸烟和饮酒与杜普伊特伦病 (DD) 之间的因果关系.
- 使用门德尔的随机化来评估与DD的遗传联系.
- 区分吸烟和酒精对DD的独立因果影响.
主要方法:
- 使用公开可用的全基因组关联研究 (GWAS) 数据采用双样本孟德尔随机化 (MR).
- 评估了每周饮料,每天吸烟,开始吸烟,开始吸烟的年龄和戒烟对DD的因果影响.
- 使用逆方差加权 (IVW) 进行初级分析,具有灵敏度和双向MR用于稳定性和相互作用.
主要成果:
- 在每周饮酒量较高和DD的几率增加之间发现了显著的因果关系 (OR=2.948).
- 在吸烟变量 (每天的香烟,开始,开始年龄,戒烟) 和DD之间没有发现因果关系.
- 双向MR证实了开始年龄和每周饮酒之间的强有力的因果关系;酒精对DD的影响与吸烟无关.
结论:
- 这项门德尔随机化研究提供了酒精消费与杜普伊特伦病之间的因果关系的证据.
- 吸烟和杜普伊特伦病之间没有建立起因果关系.
- 研究结果表明,酒精摄入量是预防DD的可修改风险因素.
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