突变性链球菌是早期儿童脏病的风险预测因素吗? 一个系统的审查和元分析
Sheetal Manchanda1, Divesh Sardana2, Simin Peng1
1Department of Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong S.A.R, Hong Kong.
BMC oral health
|September 7, 2023
概括
幼儿的突变性链球菌是未来的重要风险预测因素. 早期检测这些细菌可以帮助实施有效的预防性牙科策略.
科学领域:
- 儿科牙科 儿科牙科
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 患有初级牙的儿童的牙发育是一个重大问题.
- 突变性链球菌与牙的开始和进展有关.
研究的目的:
- 确定突变性链球菌在患有初级牙的儿童中病变的发展中的风险可预测性.
- 综合关于突变性链球菌和幼儿脏病发展之间的关联的证据.
主要方法:
- 一个系统的审查和对纵向观测研究的元分析.
- 包括至少6个月的随访时间,在6岁以下的无虫儿童中进行的研究.
- 使用纽卡斯尔-太华尺度对偏见风险的评估以及使用GRADE对证据的确定性.
主要成果:
- 包括12项研究,其中大多数显示偏差风险低至中等.
- 患有突变性链球菌的儿童患病的几率大约是4倍 (OR = 4.13).
- 观察到一个很大的效果大小 (SMD = 0.85) 对于未来的虫的经验在与基线突变性链球菌的儿童.
结论:
- 在学龄前儿童中突变性链球菌的存在是未来脏病的可靠风险预测指标.
- 早期识别被突变性链球菌殖民的儿童对于有针对性的预防干预至关重要.
- 适度的证据确定性支持突变性链球菌在病发展中的作用.
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