三甲糖-葡萄糖指数和心力衰竭:一个系统的审查和元分析
Amirmohammad Khalaji1,2,3, Amir Hossein Behnoush4,5,6, Shaghayegh Khanmohammadi1,2
1School of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd., 1417613151, Tehran, Iran.
Cardiovascular diabetology
|September 7, 2023
概括
甘油三糖 (TyG) 指数是预测心力衰竭 (HF) 风险和预后的可靠标记. 提升的TyG水平与HF发病率增加和HF患者的不良结果有关.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 生物标志物 生物标志物
背景情况:
- 胰岛素抵抗 (IR) 是心力衰竭 (HF) 中的一个关键代谢障碍,影响患者的预后.
- 甘油三糖 (TyG) 指数是HF中IR的替代标记物.
- 在高频中TyG指数的临床可靠性仍在调查中.
研究的目的:
- 系统地审查和分析有关高频TyG指数的现有研究.
- 确定TyG指数是否是HF风险和预后的可靠临床标志物.
主要方法:
- 进行了主要科学数据库 (PubMed,Embase,Scopus,Web of Science) 的系统搜索.
- 包括研究研究了HF患者的TyG指数或其与HF发病率的关联.
- 随机效应元分析被用于组合调整的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 分析了30项涉及772,809名参与者的研究.
- 较高的TyG指数水平显著增加了HF风险 (HR 1.21,95% CI 1.14-1.29) 和发病率 (HR 1.17,95% CI 1.08-1.26).
- 提升的TyG与2型糖尿病或冠状动脉疾病患者的高HF发病率,以及HF患者的不良事件有关.
结论:
- 泰格指数是评估整个人口中HF发病率风险的有价值标志物.
- 泰格指数作为HF患者的预后标记.
- 建议进行进一步的研究来证实这些关联并探索临床实用性.
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