酸桃补充酸盐混合物对痛风患者的有效性和安全性:一项前性随机受控研究
Can Wang1,2,3, Wenyan Sun2, Nicola Dalbeth4
1Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of Gout, the Affiliated Hospital of Qingdao University, Qingdao, China.
Arthritis research & therapy
|September 7, 2023
概括
酸花酸盐补充剂在痛风患者中没有改变尿液pH或血清尿酸盐,但改善了功能和减少了炎症. 这些发现表明,与尿酸降低疗法一起,对痛风管理有潜在的益处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 营养科学 营养科学
背景情况:
- 尿液pH值低在痛风中很常见,可能与代谢综合征 (MetS) 相关.
- 酸桃可以改善MetS症状,并提供抗炎作用.
- 酸补充剂对痛风患者尿液pH的影响尚未研究.
研究的目的:
- 为了评估酸桃补充酸盐 (TaCCi) 混合物的有效性和安全性.
- 评估TaCCi对尿液pH,血清尿酸 (sUA),C反应蛋白 (CRP) 和开始尿酸降低疗法 (ULT) 的痛风患者的痛风爆发的影响.
- 为了比较TaCCi与酸盐混合物和二碳酸.
主要方法:
- 一项前性,随机的,开放的,并行控制的试验,涉及282名患有痛风和尿液pH值低 (≤6) 的男性.
- 参与者用febuxostat启动ULT,并随机分配给接受二碳酸,酸盐混合物或TaCCi混合物.
- 随访每4周进行一次,直到第12周,尿液pH和sUA作为共同主要结局.
主要成果:
- 在所有三组中,尿液pH和sUA水平都相似地下降.
- 与对照组相比,TaCCi混合组显示尿中的白蛋白/肌素比率 (UACR) 显著降低.
- 与碳酸相比,TaCCi和酸盐混合物减少了痛风发作;TaCCi也更显著地降低了CRP水平.
结论:
- 酸桃酸盐混合物在痛风患者的尿液化和SUA减少方面表现出与酸盐和二碳酸相比的有效性和安全性.
- 补充TaCCi导致UACR和CRP的更大改善,这表明潜在的脏保护和抗炎功效.
- 酸补充剂可能为痛风患者提供额外的优势,特别是在ULT启动期间.
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