三甘油糖指数是U形,与心血管疾病患者全因死亡率相关
Haiyu Li1, Yaohui Jiang1, Xin Su1
1Department Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
甘油三和葡萄糖 (TyG) 指数显示了心血管疾病患者与所有原因死亡率的U形关联. 观察到的死亡风险最低的TyG指数水平在8.83和9.06之间.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 公共卫生 公共卫生
背景情况:
- 甘油三和葡萄糖 (TyG) 指数是胰岛素抵抗和死亡风险的标志物.
- 很少有研究研究了TyG指数与心血管疾病 (CVD) 患者全因死亡率的具体联系.
研究的目的:
- 调查TyG指数与心血管疾病患者全因和心血管死亡率之间的关联.
主要方法:
- 利用了来自NHANES (1999-2014) 的2,072名心血管疾病参与者的数据.
- 计算的TyG指数:日志[禁食甘油三 (mg/dL) x禁食葡萄糖 (mg/dL) /2].
- 采用考克斯回归模型和受限立方线来分析死亡风险.
主要成果:
- 在16.8年的时间里,791人死于各种原因,184人死于心血管疾病.
- 在TyG指数和全因死亡率 (p < 0.001) 之间发现了一个非线性,U形的关联.
- 最低的全因死亡风险与8.839.06.06的TyG指数水平有关. 没有发现与心血管死亡率有任何关联.
结论:
- TyG指数与心血管疾病患者的全因死亡率呈现出U形关系.
- 降低死亡风险的最佳TyG指数水平在8.83至9.06之间.
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