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生物膜如何改变我们对清洁和消毒的理解?
Jean-Yves Maillard1, Isabella Centeleghe2
1School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, Wales, UK. maillardj@cardiff.ac.uk.
Antimicrobial resistance and infection control
|September 7, 2023
概括
医疗保健机构中的生物膜构成重大威胁,导致与医疗保健相关的感染 (HAI). 有效的控制需要了解不同的生物膜类型和专门的测试方法.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 医疗卫生流行病学 医疗卫生流行病学
背景情况:
- 生物膜在医疗环境中普遍存在,并且本质上对抗微生物药物具有耐药性.
- 这种抗性归因于诸如细胞外聚合物质矩阵和eDNA等因素.
- 生物膜作为病原体的储存库,包括多种耐药生物体,有助于医疗相关感染 (HAI).
研究的目的:
- 突出在医疗保健环境中控制生物膜的挑战.
- 要区分水合和干燥表面生物膜 (DSB) 以及它们的控制策略.
- 强调需要进行标准化疗效测试和教育利益相关者,以更好地管理生物膜.
主要方法:
- 对生物膜特征及其在HAI中的作用的审查.
- 液化和干燥表面生物膜 (DSB) 和它们各自的控制指标之间的区别.
- 对标准化生物膜测试协议当前局限性的分析.
主要成果:
- 生物膜耐药性是多因素的,受到矩阵组成和多种相互作用的影响.
- 有两种主要的生物膜类型:水合 (例如,排水管) 和干表面生物膜 (DSB).
- 控制策略必须量身定制,水合生物膜需要降低生物负担和再生监测,而DSB控制涉及降低生物负担和减少细菌转移.
结论:
- 有效的生物膜控制需要水合和DSB的不同的方法.
- 缺乏标准化测试协议阻碍了有效的管理,并增加了HAI风险.
- 教育利益相关者和开发特设疗效测试对于改善医疗保健中的生物膜控制至关重要.
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