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发育中的小鼠大脑中的性别偏差基因和microRNA表达与神经发育功能和神经现象类型有关

Susanna Szakats¹, Alice McAtamney¹, Hugh Cross¹

¹Developmental Genomics Laboratory, Department of Anatomy, School of Biomedical Sciences, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.

Biology of sex differences

|September 7, 2023

概括

生物性别影响发育中的大脑中的基因表达,在男性和女性之间观察到不同的微RNA (miRNA) 模式. 这些性别偏差的miRNAs可能在神经发育障碍中发挥作用.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
发展生物学发展生物学

背景情况:

疾病发病率中的性别差异凸显了了解生物性别在健康和疾病中的作用的需要.
性染色体和荷尔蒙显著影响疾病机制,特别是神经发育障碍,如多动症,精神分裂症和自闭症.
基因表达是性别特异性发育过程的关键调解者.

研究的目的:

为了研究发育中的大脑中微RNA (miRNA) 表达的性别差异.
为了确定特定的miRNAs与男性和女性胚胎大脑之间的差异性表达.
探索性别偏差miRNAs在神经发育和相关疾病中的潜在作用.

主要方法:

利用高通量测序来识别具有显著性别偏差表达的转录,包括miRNAs.
在胚胎日15.5 (E15.5) 分析了雄性和雌性小鼠大脑的基因表达差异.
进行基因本体学分析和挖掘SNP数据,将性别偏差RNA与神经发育途径和疾病联系起来.

主要成果:

在发育中的大脑中,确认了某些基因和miRNAs在表达中的强烈性别差异.
确定了许多具有显著性别偏差表达的miRNAs,其中许多已知参与神经发育.
基因本体学分析揭示了受性别偏差RNA影响的广泛功能类别,SNP数据将一些miRNA与神经发育障碍风险位置联系起来.

结论:

这些发现强调了在分子研究中考虑生物性别的重要性.
突出了特定的基因,miRNA和潜在参与大脑性差异化的途径.
结果表明,性别偏差的miRNA表达可能导致神经发育和易受疾病的性别差异.

关键词:

大脑发育大脑发育补偿补偿补偿补偿神经发育神经发育神经发育障碍神经发育障碍性偏见的性别偏见这是一个微型RNA.

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