在大脑麻的成年人中,将皮质脊柱管激活和上肢运动控制联系起来
Saihari S Dukkipati1, Sarah J Walker1, Michael P Trevarrow1
1Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, USA.
Developmental medicine and child neurology
|September 8, 2023
概括
在大脑麻 (CP) 的成年人中,椎骨运动唤起潜力 (CMEPs) 发生变化与上肢运动功能的减少有关. 这些发现表明,皮质脊柱路径的变化会影响CP的运动控制.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 临床神经学 临床神经学
背景情况:
- 大脑 (CP) 通常涉及运动障碍,特别是影响上肢功能.
- 底层的神经机制,特别是涉及皮质脊髓通路和脊髓运动神经元激活,需要进一步阐明.
研究的目的:
- 量化宫骨髓运动唤起潜力 (CMEPs) 在宫脊髓水平在成人CP.
- 研究CP患者中改变的CMEP与上肢运动功能之间的关系.
主要方法:
- 一个横截面研究,比较CP的成年人 (n=15) 和神经类型对照 (n=18).
- 通过宫髓结刺激来评估CMEP.
- 用标准化测试 (Box and Blocks,Purdue Pegboard),自我报告功能和选择性运动控制评估来评估上肢运动功能.
主要成果:
- 与在更高刺激水平 (p=0.032) 的对照组相比,患有CP的成年人表现出不同的对应CMEP反应.
- 降低的CMEP与较差的上肢功能显著相关,包括运动任务的性能下降和较低的自我报告功能 (p<0.025).
结论:
- 脊柱运动神经元通过皮质脊柱通路的改变激活可能导致CP患者上肢观察到的运动缺陷.
- 量化CMEP提供了一个潜在的生物标志物,用于评估CP的机动路径完整性.
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