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Updated: Jul 17, 2025

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
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斯皮诺辛通过非活化p38保护Neuro-2a/APP695细胞免受氧化应激损伤

Zhang Xiaoying1, Wang Ruixuan1, Wang Yiqing2

  • 1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
|September 8, 2023
PubMed
概括

斯皮诺辛通过抑制p38通路来保护阿尔茨海默病模型细胞免受氧化压力. 这项研究提供了对阿尔茨海默病潜在治疗策略的见解.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的疾病氧化应激是一种氧化应激.p38 线素激活蛋白质激酶的作用.脊髓瘤是一种脊髓瘤

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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