在实验性性结肠炎上,水溶性中国的潜在保护作用
Zhou Hua1, L I Hui2, Wang Haihua2
1Department of Physiology, Anhui Medical College, Hefei 230601, China.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
|September 8, 2023
概括
中国水溶性 (WSP) 在性结肠炎 (UC) 的大鼠模型中有效降低了炎症和氧化应激. 治疗效果是剂量依赖的,为UC提供了潜在的自然治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 自然产品 自然产品
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,其特征是结肠粘膜损伤.
- 氧化应激 (OS) 在UC的发病过程中起着重要作用.
- 探索用于UC治疗的天然化合物是一个活跃的研究领域.
研究的目的:
- 研究中国水溶性 (WSP) 对大鼠DSS诱导的性结肠炎的治疗作用.
- 评估WSP对结肠粘膜炎症反应和氧化应激的影响.
- 在实验性UC模型中确定WSP的剂量依赖疗效.
主要方法:
- 在使用硫酸 (DSS) 的雄性大鼠中确立的性结肠炎 (UC).
- 作为治疗组,服用不同剂量的水溶性 (WSP) 和硫沙 (Sulfa).
- 评估疾病活动,结肠长度,粘膜损伤,并测量了炎症标志物 (MPO,IL-6,IL-9,TNF-ɑ) 和氧化应激指标 (SOD,MDA,GSH-Px) 的水平.
主要成果:
- 由DSS诱导的UC大鼠表现出增加的促炎性细胞因子表达和氧化应激 (OS).
- 在剂量依赖的情况下,WSP治疗显著降低了促炎性细胞因子水平和OS.
- 通过WSP干预,改善了疾病活动指数,减少了血的便,并减轻了结肠损伤.
结论:
- 在性结肠炎 (UC) 的实验模型中,水溶性 (WSP) 显示出显著的抗炎和抗氧化特性.
- 通过增强内源性抗氧化酶 (SOD,GSH-Px) 和抑制中性粒细胞活性,WSP降低了氧化应激.
- 通过减少关键的促炎细胞因子 (TNF-ɑ,IL-6,IL-9),WSP减轻肠道炎症,表明其作为UC治疗剂的潜力.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
168
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
168
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
488
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
488
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
460
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
460
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
544
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
544
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
463
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
463


