用于阿尔茨海默病的吉林吉囊:随机非劣势受控试验的二次分析
Zhao Ming1, Luo Yimiao2, Wang Huichan2
1Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
|September 8, 2023
概括
吉林吉囊 (GLJC) 在改善阿尔茨海默氏症患者的认知功能和生活质量方面,显示出与银杏提取物片效率相当的效果. GLJC在管理传统中医症状和抗衰老作用方面提供了额外的好处.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 阿尔茨海默病 (AD) 构成了全球重大健康挑战,特别影响认知功能和日常生活.
- 髓缺陷模式 (KMDP) 是一种与AD相关的公认的传统中医 (TCM) 模式.
- 研究新的阿尔茨海默病治疗策略,包括基于TCM的干预措施,至关重要.
研究的目的:
- 为了评估Guilingji囊 (GLJC) 与银杏取物片相比在治疗KMDP的AD患者中的疗效和安全性.
- 评估GLJC对认知功能,日常生活活动和TCM特异性症状的影响.
- 分析GLJC对关键生物化学标志物的影响,这些标志物与AD病原和细胞衰老有关.
主要方法:
- 一个多中心随机非劣等性临床试验的二次分析,涉及120名KMDP的AD患者.
- 参与者被随机分为两组:GLJC (n=60) 和金科提取物片 (n=60).
- 评估包括迷你精神状态检查 (MMSE),阿尔茨海默病评估量表-认知子量表 (ADAS-Cog),日常生活活动 (ADL),中医症状量表 (CM-SS) 和血清标记分析 (Ach,AchE,Bcl-2,Bax) 在基线和24周.
主要成果:
- 无论是GLJC还是金科提取物,都显著改善了MMSE得分,并降低了ADAS-Cog,ADL和CM-SS得分 (p < 0.01).
- 在12周和24周,GLJC在改善"失忆症"和"沉默表情和思维缓慢"症状方面表现出更高的有效率 (p < 0.05,p < 0.01).
- GLJC显著增加了血清Bcl-2水平 (p < 0.05),而两组都显示了血清Bax和AchE水平的降低 (p < 0.01);没有报告任何不良事件.
结论:
- 在提高KMDP的阿兹海默症患者的认知功能和生活质量方面,GLJC不逊色于银杏取物片.
- GLJC在解决特定的TCM症状方面表现出卓越的疗效,并具有潜在的抗衰老特性.
- 在KMDP的患者中,GLJC为AD的管理提供了安全有效的治疗选择.
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