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基细胞激活试验作为预测对蛋过敏反应严重程度和值的指标
Suzana Radulovic1,2, Ru-Xin Foong1,2,3, Irene Bartha1,2
1Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Allergy
|September 8, 2023
概括
基细胞激活试验 (BAT) 能够有效预测患有蛋过敏的儿童的严重过敏反应和低反应值. 这种生物标志物有助于在临床决策中管理蛋过敏.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科过敏 儿科过敏
- 食物过敏研究 食物过敏研究
背景情况:
- 准确识别患有严重过敏反应风险的患者至关重要,特别是对于像蛋这样的常见食品.
- 了解反应性值有助于控制食物过敏并预防严重反应.
研究的目的:
- 评估基激活试验 (BAT) 在预测对蛋过敏反应的严重程度和反应性值方面的有效性.
- 将BAT与其他免疫标记物 (如特定IgE (sIgE)) 进行比较,以预测蛋过敏的严重程度.
主要方法:
- 150名儿童接受了双盲安慰剂控制的食物挑战 (DBPCFC) 烤蛋 (BE) 和松蛋 (LCE).
- 进行了皮肤刺伤测试,针对特定IgE的血清学和基细胞激活测试 (BAT).
- 反应按严重程度分类,并在DBPCFC期间确定值剂量.
主要成果:
- 在DBPCFC期间,40%的儿童对BE和21%的儿童对LCE做出反应.
- 在BE反应器中,38%的反应严重,55%的反应率值低 (≤0.13g蛋蛋白).
- 严重的BE反应堆显示出更高的ovomucoid-sIgE和BAT结果. 低值患者具有更高的特定IgE活性和BAT结果.
结论:
- 与sIgE相比,基激活试验 (BAT) 在预测卵子过敏的严重程度和反应性值方面表现出更高的准确性.
- 最佳技术是蛋过敏管理中的临床决策的宝贵生物标志物.
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