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超声波特征与基底细胞癌 (BCCs) 中Bcl-2蛋白表达的相关性
Ping-Ping Luo1, Yan-Xuan Chen1, Zhi-Rong Zhong1
1Department of Ultrasound, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
Journal of clinical ultrasound : JCU
|September 8, 2023
概括
超声波特征与基底细胞癌 (BCC) 中的Bcl-2表达相关. 低BCL-2表达BCC显示更深的透和更多的囊性变化,有助于治疗选择.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- Bcl-2蛋白表达是基底细胞癌 (BCC) 的关键标记物.
- 皮肤超声波提供皮肤瘤的非侵入性解剖数据.
研究的目的:
- 为了将超声波特征与BCC中的Bcl-2表达相关联.
- 为了告知BCC的药理治疗策略.
主要方法:
- 74个BCC根据BCL-2表达 (高与低) 进行分类.
- 术前超声波特征被追溯分析,使用已确定的标准.
- 统计分析 (基平方,配对的t测试) 比较了组.
主要成果:
- 低Bcl-2表达BCCs (LB-BCCs) 显示出更频繁的囊区域 (P=.008).
- 在LB-BCC中,透深度 (P=.000) 和皮下组织入侵程度 (P=.002) 较大.
- 在LB-BCC中,内部多普勒信号更为丰富 (P=.000).
结论:
- 超声波特征与BCC中的BCL-2蛋白表达水平相关.
- LB-BCCs显示透深度增加,皮下侵袭,囊性变化和多普勒信号.
- 这些发现可能会指导BCC化疗药物选择.
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