RISREAC研究:通过临床文档评估皮肤辐射损伤
Aqsa Ghaffar1, Yunna Xie2, Peter Antinozzi3
1School of Medicine & Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
Disaster medicine and public health preparedness
|September 8, 2023
概括
从临床笔记开发辐射诱导皮肤反应 (RISREAC) 队列是可行的. 这种研究辐射性皮肤炎 (RD) 和皮肤辐射损伤 (CRI) 的新方法显示出更好的记录和患者护理的希望.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 医疗信息学 医疗信息学
背景情况:
- 辐射皮肤炎 (RD) 影响95%接受放射治疗 (RT) 的患者.
- 现有的RD分级方法,如放射治疗瘤学组 (RTOG) 和不良事件的常见毒性标准 (CTCAE),都有局限性.
- 需要一种更可靠的方法来记录和评估辐射诱导的皮肤变化.
研究的目的:
- 为了证明建立一个研究RD的历史队列的可行性,命名为辐射诱导皮肤反应 (RISREAC) 队列.
- 评估接受RT的乳腺癌患者的RD的进展,得分和管理.
- 将 RD 症状描述者的可靠性与现有的分级系统进行比较.
主要方法:
- 对245名接受RT的乳腺癌患者进行了回顾性研究.
- 评估了与RD相关的临床文档,以了解RD进展,得分和管理.
- 进行了统计分析,以评估临床医生记录的严重程度和基于描述者的得分之间的相关性.
主要成果:
- 在169名 (69%) 患者中观察到临床医生记录的RD严重程度,平均严重程度为1.57.
- 基于描述符的平均严重性得分为2.31,显示了与已记录的RD等级的中等相关性 (r = 0.532,P < 0.0001).
- 大多数患者 (91.8%) 在RT期间接受皮肤护理治疗,66.7%接受多种治疗方式.
结论:
- RISREAC队列是研究辐射诱导的皮肤变化的第一个回顾性队列.
- 与RTOG或CTCAE等级相比,RD症状描述符的记录更加可靠,适用于所有皮肤类型.
- 一个新的基于描述符的评分工具可能有利于评估RD和皮肤辐射损伤 (CRI).
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