一项系统性审查评估了运动训练对前列腺癌患者进行雄激素剥夺治疗的身体状况的有效性
Fan Yuan1,2, Yang Wang3, Xiwei Xiao4
1Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Translational andrology and urology
|September 8, 2023
概括
运动训练可以改善前列腺癌患者接受雄激素剥夺疗法 (ADT) 的身体状况. 适度的证据表明身体组成,力量和生活质量有所改善,而低的证据表明对疲劳和其他症状有好处.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 基于证据的医学基于证据的医学.
背景情况:
- 安卓素剥夺疗法 (ADT) 是前列腺癌 (PCa) 的标准治疗方法.
- 接受ADT的患者经常体验身体状况下降.
- 运动在减轻这些影响中的作用需要进行系统的评估.
研究的目的:
- 系统地审查和总结现有的系统性审查和元分析 (SRs/MAs).
- 评估运动训练对接受ADT的PCa患者身体状况的影响.
主要方法:
- 在8个数据库中对2022年4月之前以英语或中文出版的SR / MA进行了全面的文献搜索.
- 包括的SRs/MAs被评估为使用AMSTAR 2,ROBIS,PRISMA和GRADE工具的方法论,偏见,报告和证据质量.
- 综合了来自8个SR/MA的数据,包括94个研究和51个结局.
主要成果:
- 质量评估显示,大多数SRs/MAs的方法质量低至非常低,偏差风险高.
- 没有发现高质量的证据;中等质量的证据表明,运动可以改善身体组成,肌肉力量和生活质量.
- 低质量的证据表明,运动可以缓解疲劳,抑郁,性功能障碍,并改善心脏代谢参数.
结论:
- 运动训练显示出作为PCa患者在ADT上的辅助疗法的潜力,改善一般健康方面.
- 需要进一步研究严格的设计和更大的样本大小,以加强证据基础.
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