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多发性硬化症表型之间的元认知差异:认知障碍和疲劳是关键因素
Clàudia Coll-Martinez1,2,3, Judit Salavedra-Pont1,2, Maria Buxó4
1Girona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department, Dr. Josep Trueta University Hospital and Santa Caterina Hospital, Girona, Spain.
Frontiers in psychology
|September 8, 2023
概括
患有多发性硬化症 (MS) 的患者通常具有认知障碍和对这些缺陷的不准确自我意识. 疲劳和残疾显著影响MS患者如何感知他们的认知能力.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 神经学 神经学
背景情况:
- 认知障碍影响了40-65%的多发性硬化症患者 (pwMS).
- 客观测量的认知功能与MS患者自我感知的认知能力之间经常存在显著的脱节.
- 了解这种差异对于管理这种情况至关重要.
研究的目的:
- 为了比较pwMS和健康对照 (HCs) 之间的认知表现和认知缺陷的自我感知.
- 与客观表现相比,评估 pwMS 中认知能力的自我感知准确度.
- 识别导致自我评估不准确的因素.
主要方法:
- 神经心理学评估和自我报告尺度 (感知缺陷,疲劳,焦虑-抑郁) 给了112名pwMS (包括复发性复发性MS和进展性MS) 和54名HC.
- 参与者根据他们主观自我评估和客观认知表现之间的一致性进行了分类.
- 回归模型分析了认知性能差异和影响估计不准确性的因素.
主要成果:
- 与HC相比,进展性MS (PMS) 患者表现出比复发性复发性MS (RRMS) 患者更明显的认知差异.
- 在pwMS和HC之间没有发现感知认知缺陷的显著差异.
- 前综合征患者的认知能力高估率较高.
- 疲劳和认知维护与低估有关,而身体残疾和认知障碍与高估有关.
结论:
- 患有多发性硬化症的患者表现出对元认知知识的损害,影响对认知缺陷的自我意识.
- 该研究强调了大量多发性硬化队列中超认知障碍的普遍性,并确定了关键影响因素.
- 在pwMS中可能存在无意识,缺乏对自身状况的洞察力,疲劳是低估认知功能的关键因素.
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