患有严重抑郁症患者的炎症标志物:来自印度的前性,临床基础的队列研究
Sucharita Mandal1, Mamidipalli Sai Spoorthy2, Sangha Mitra Godi3
1Psychiatry, All India Institute of Medical Sciences, Kalyani, Kalyani, IND.
Cureus
|September 8, 2023
概括
炎症标志物,如瘤亡因子-α (TNF-α) 和互白素-10 (IL-10) 可能是主要抑郁障碍的特征标志物,而不仅仅是后果. 在治疗期间水平发生了变化,但没有显著变化.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁症 (MDD) 的治疗反应因不坚持,并发症和生物影响等因素而有所不同.
- 炎症标志物 (亲和抗炎症) 涉及到抑郁症的病因,作为诱导因素,以及后果.
- 研究的关键标志物包括白细胞间蛋白 (IL),干扰素,C反应蛋白 (CRP) 和瘤缩因子-α (TNF-α).
研究的目的:
- 评估MDD患者的炎症标志物水平.
- 为了比较和关联抑郁症治疗前和治疗后阶段的亲和抗炎标记物变化.
- 为了评估患者实现缓解或治疗反应积极的标志物模式.
主要方法:
- 长达1.5年的前性,基于临床的队列研究.
- 包括81名患有MDD (ICD-10) 和汉密尔顿抑郁症评分表>7.7的患者 (18-65岁).
- 评估了31名完成者在基线,2,4周和8周的瘤坏死因子-α (TNF-α) 水平.
主要成果:
- 支持炎症的细胞因子TNF-α水平从基线增加到8周.
- 抗炎性标志物IL-10水平显示,从基线下降趋势到8周.
- 这些观察到的TNF-α和IL-10水平的变化在统计学上并不显著.
结论:
- 这项研究支持这样一个假设:炎症标志物可能作为抑郁症的特征标志物.
- 炎症标志物可能是抑郁症的固有特征,而不是仅仅是疾病的后果.
- 需要进一步的研究来阐明这些标记物在MDD病理生理学中的作用.
更多相关视频
相关概念视频
Depressive Disorders: MDD and Dysthymia
154
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
154
Depressive Disorders: Etiology
119
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
119
Depression: Overview
274
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
274
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
118
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
118


