评估使用类固醇类固醇和食补充剂的健美运动员的功能
Sultan Ozkurt1, Engin Ozakin2, Hilal Gungor3
1Nephrology, Faculty of Medicine, Eskişehir Osmangazi Üniversitesi, Eskişehir, TUR.
Cureus
|September 8, 2023
概括
类固醇类固醇 (AAS) 和食补充剂 (DS) 用户的估计球过率 (eGFR) 基于cystatin C较低.使用AAS+DS的健美运动员也表现出更高的尿和蛋白质水平,这表明潜在的早期脏损伤.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 运动医学 运动医学
- 内分泌学 在内分泌学.
背景情况:
- 合成安卓类固醇 (AAS) 和食补充剂 (DS) 在健美运动员中很普遍.
- 在这种人群中,基于肌素的估计膜过率 (eGFRcr) 可能被低估,因为肌肉质量和使用肌素.
- 基于赛斯塔丁C的方程提供了独立于肌肉质量的更可靠的GFR评估.
研究的目的:
- 为了评估使用AAS+DS的健美运动员的功能,与仅使用DS的用户相比.
- 为了评估膜过率 (GFR),使用囊素C (eGFRcys) 和结合囊素C/肌素 (eGFRcys/cr) 方程.
- 在这些群体中调查损伤的尿路标志物.
主要方法:
- 包括使用AAS+DS的12名健美运动员和使用DS的12名健美运动员.
- 测量血清囊素C,eGFRcys,eGFRcys/cr,尿蛋白和蛋白质分泌率.
- 两组之间功能标志物的比较.
主要成果:
- 使用AAS+DS的患者尿中白蛋白/肌素和蛋白质/肌素的比率显著提高.
- 虽然eGFRcr类似,但在AAS+DS组,eGFRcys和eGFRcys/cr显著较低.
- 平均AAS使用时间为3.08年,DS使用时间为3.67年.
结论:
- 在AAS+DS使用者中,基于cystatin C的GFR显著降低.
- 尿路白蛋白和蛋白质分泌量升高表明AAS+DS使用者可能早期损伤.
- 需要进一步的研究来证实AAS使用与脏损伤之间的联系.
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