便微生物群是中国患者精神分裂症和多发性硬化症共存的基础
Li Shao1, Jinlong Fu1, Lulu Xie2
1School of Clinical Medicine, Institute of Hepatology and Metabolic Diseases, Hangzhou Normal University, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
概括
便微生物群,特别是便细菌的较低水平,可能通过改变肠道细菌和血清细胞因子,将精神分裂症和多发性硬化症联系起来. 这表明两种情况都有潜在的肠道向疗法.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 精神分裂症 (SZ) 和多发性硬化症 (MS) 是具有重大社会影响的普遍疾病.
- 现有研究表明,SZ和MS之间存在双向关系,但潜在的机制尚不清楚.
- 肠道微生物群在大脑功能调节中的作用凸显了其在这些复杂疾病中的潜在参与.
研究的目的:
- 调查精神分裂症和多发性硬化症患者的便微生物群和血清细胞因子概况.
- 确定可能将这两种不同的神经疾病联系在一起的共享微生物和免疫学变化.
- 探索肠道微生物群作为治疗目标的潜力,用于管理SZ和MS.
主要方法:
- 对90名中风患者,22名多发性硬化患者和匹配对照组的便微生物组组成和血清细胞因子水平的分析.
- 对微生物多样性和疾病队列之间的差异性属的比较分析.
- 特定微生物属和血清细胞因子水平之间的相关性分析.
主要成果:
- 无论是SZ还是MS患者都表现出类似的微生物多样性,并共享了三个差异性属:下调的*Faecalibacterium*和*Roseburia*,和上调的*Streptococcus*.
- 观察到血清细胞因子变化的明显模式,TNF-α,IL-8和MIP-1α在两种疾病中都受到干扰.
- *Faecalibacterium*与血清细胞因子有显著的相关性,尤其是与TNF-α的负相关性,这表明它在疾病相互作用中的作用.
结论:
- 便微生物群的改变,特别是便细菌的减少,可能导致精神分裂症和多发性硬化症的同时发生.
- 肠道微生物群对血清细胞因子的影响呈现出将这些神经系统疾病联系在一起的潜在机制.
- 这些发现支持开发针对肠道微生物群的向疗法,同时管理SZ和MS.
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