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Updated: Jul 17, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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Published on: January 24, 2016

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SARS-CoV-2 Nsp15通过抑制IRF3酸化和核转位来抑制I型干扰素的产生

Dianqi Zhang1,2,3, Likai Ji2, Xu Chen2,4

  • 1Clinical Laboratory Center, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou 225300, China.

iScience
|September 8, 2023
PubMed
概括

SARS-CoV-2 Nsp15 蛋白质通过阻断干扰素生产和 IRF3 激活来抑制宿主免疫反应. 它通过干扰TBK1激酶活性和促进IRF3降解来实现这一目标.

关键词:
细胞生物学 细胞生物学免疫学 免疫学 免疫学病毒学 病毒学

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