急性有氧运动对类风湿性关节炎患者脑源性神经营养因子水平的影响
Songül Bağlan Yentur1, Zübeyde Ercan1, Gülnihal Deniz2
1Department of Physiotherapy and Rehabilitation, Fırat University Faculty of Health Science, Elazığ, Türkiye.
Archives of rheumatology
|September 8, 2023
概括
急性有氧运动降低了类风湿性关节炎 (RA) 患者和对照者的血清脑衍生神经营养因子 (BDNF) 水平. RA 患者在 BDNF 中表现出更大的变化,这与焦虑和抑郁症得分相关.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 运动生理学 运动生理学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病.
- 大脑衍生神经营养因子 (BDNF) 在神经元健康和炎症中起作用.
- 运动经常被推用于 RA 管理,但其对 RA 患者 BDNF 的影响尚未完全理解.
研究的目的:
- 为了研究有氧运动对RA患者血清BDNF水平的急性影响.
- 为了比较RA患者和健康对照人群在单次运动会后的BDNF水平变化.
- 探索BDNF变化与RA患者焦虑和抑郁等心理因素之间的关系.
主要方法:
- 一项涉及88名参与者的横截面研究 (44名RA患者,44名健康对照).
- 所有参与者都进行了一次有氧运动.
- 在运动前和运动后立即测量血清BDNF水平.
- 用验证的问卷进行了抑郁和焦虑的评估.
主要成果:
- 在RA患者和对照人群中,基线和运动后血清BDNF水平在RA患者和对照人群之间是可比的.
- 在这两组中,有氧运动导致血清BDNF水平显著下降.
- 与对照组相比,RA组BDNF水平 (ΔBDNF) 的变化在RA组显著更大.
- 在RA患者中,ΔBDNF与焦虑和抑郁的得分有显著的相关性.
结论:
- 单次有氧运动可以降低RA患者和健康人群的血清BDNF水平.
- 与对照人群相比,RA患者在运动后表现出BDNF急性降低更明显.
- 这些发现表明,运动诱导的BDNF变化与RA中的心理状态之间存在潜在的联系.
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