门德尔的随机分析揭示了肠道微生物群-乳腺轴在乳腺癌中的作用
Shuwan Zhang1,2, Wenchuan Zhang1, Haiyue Ren1
1Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Frontiers in microbiology
|September 8, 2023
概括
这项研究使用了门德尔的随机化来探索肠道微生物群.
科学领域:
- 微生物组研究的研究.
- 癌症流行病学癌症流行病学
- 遗传学 遗传学 是一个
背景情况:
- 观察性研究表明,肠道微生物群和乳腺癌之间存在联系.
- 肠道微生物群和乳腺癌风险之间的因果关系尚不清楚.
研究的目的:
- 研究肠道微生物群对乳腺癌风险的因果关系.
- 分析与乳腺癌亚型的关联.
主要方法:
- 两个样本的孟德尔随机化 (MR) 分析.
- 利用了肠道微生物组和乳腺癌的大规模全基因组关联研究 (GWAS) 数据.
- 采用逆方差加权 (IVW) 和灵敏度分析.
主要成果:
- 种类_Sellimonas 丰富度与增加ER+乳腺癌风险有关.
- 种类_Adlercreutzia丰富性显示出对ER+乳腺癌的保护作用.
- 种类_Ruminococcus2的丰富性与降低Her2+乳腺癌风险有关,而种类_Erysipelatoclostridium的丰富性与风险增加有关.
结论:
- 建立了一个肠道微生物群-乳腺轴.
- 建议肠道微生物群作为乳腺癌预防和治疗的潜在目标.
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