在呼吸道和炎症性肠道疾病中,肺肠交汇
Baoxiang Du1, Yan Fu1, Yuxiu Han1
1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in cellular and infection microbiology
|September 8, 2023
概括
常见的粘膜免疫系统连接肺和肠道. 本综述探讨了肠道微生物群如何通过肺肠交互影响呼吸系统疾病和炎症性肠病 (IBD).
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肺和肠是常见的粘膜免疫系统 (CMIS) 中的关键防御器官.
- 新出现的证据突出显示了"肺肠交声",即一个器官的情况会影响另一个器官.
- 肠道微生物群在呼吸系统和肠道健康中起着至关重要的作用.
研究的目的:
- 审查当前对呼吸道疾病和IBD肺肠交叉通话机制的理解.
- 探索肠道微生物失衡对这些疾病的影响.
- 讨论治疗策略涉及肠道菌群调节的呼吸道疾病.
主要方法:
- 关于肺肠相互作用的最近研究的文献综述.
- 对将肠道微生物群与呼吸道和胃肠道疾病联系起来的机制的分析.
- 讨论针对肠道微生物组的治疗潜力.
主要成果:
- 肠道微生物失衡与炎症性肠病 (IBD) 和呼吸道疾病 (如喘,COPD和感染) 有关.
- 肠道微生物群的破坏可能会损害肠道屏障的完整性,并促进炎症.
- 肺肠交叉声涉及到各种呼吸道和肠道疾病的发病.
结论:
- 肺肠交叉是呼吸系统疾病和IBD的一个重要因素.
- 调节肠道菌群为呼吸系统疾病提供了潜在的治疗策略.
- 需要进一步的研究才能充分阐明肺肠沟通的机制.
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