雷米马佐拉姆和普罗波对接受关节置换的老年患者出现激动的影响:一项临床,随机,受控研究
Jinjuan Duan1, Xia Ju1, Xing Wang1
1Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Anqing Municipal Hospital, Anqing, People's Republic of China.
Drug design, development and therapy
|September 8, 2023
概括
与普罗波相比,雷米马佐拉姆在老年关节置换患者中显著降低了出现动荡. 这种麻醉剂还导致手术后不良事件减少,对血液动力学影响较小.
科学领域:
- 麻醉学和外科手术期间的医学.
- 老年人手术是一项老年人手术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 突发动作 (EA) 是接受手术的老年患者的常见并发症.
- 普罗波是一种广泛使用的麻醉剂,但其与EA的关联令人担忧.
- 雷米马佐拉姆是一种较新的超短效二甲,在麻醉管理中具有潜在的优势.
研究的目的:
- 为了比较雷米马佐拉姆与普罗波福尔在减少关节置换手术的老年患者出现动荡的疗效.
- 为了评估血动力学效应和术后不良事件的发生率与雷米马佐拉姆和普罗波福相关.
主要方法:
- 一项前性,随机的,受控的研究,涉及60名接受关节置换的老年患者.
- 患者被随机分配给接受雷米马佐拉姆或普罗波,用于麻醉的诱导和维持.
- 主要结局是EA的发生率;次要结局包括心率,平均动脉压和术后不良事件.
主要成果:
- 雷米马佐拉姆组 (10%) 的EA发病率明显低于普罗波组 (33%) (P < 0.05).
- 雷米马佐拉姆组在诱导后的特定时间点显示出更高的心率和平均动脉压 (P < 0.05).
- 术后不良事件的总体发病率在雷米马佐拉姆组明显较低 (P < 0.05).
结论:
- 在接受关节置换的老年患者中,雷米马佐拉姆在减少出现动荡方面比普罗波更有效.
- 雷米马佐拉姆显示出良好的安全性,术后不良事件较少,血动力学影响较小,相比于propofol.
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