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在脑瘤患者的早期发作预防中,经外科手术后给予perampanel

Kosuke Kusakabe¹, Akihiro Inoue¹, Hideaki Watanabe¹

¹Department of Neurosurgery, Ehime University School of Medicine, Toon, Japan.

Surgical neurology international

|September 8, 2023

概括

佩拉曼奈尔 (PER) 在手术后的脑瘤患者中有效地预防了早期发作,没有严重的副作用. 这种抗药物在预防中显示出与 levetiracetam (LEV) 相同的安全性和有效性.

科学领域:

神经瘤学神经瘤学
临床药理学临床药理学
发病学 (Epileptology) 是一个专业的学科.

背景情况:

关于在前脑患者的外科手术期间抗药物 (AED) 预防,存在争议.
质母细胞瘤 (GBM) 是一种常见的大脑瘤,发作风险令人担忧.
对于外科手术期间预防发作,研究像佩拉曼内尔 (PER) 这样的新型抗药至关重要.

研究的目的:

评估perampanel (PER) 预防脑瘤患者早期发作的疗效和安全性.
在类似的患者队列中比较PER与 levetiracetam (LEV) 的有效性.
评估与外科期PER施用相关的不良事件和毒性.

主要方法:

对45名接受PER治疗的脑瘤患者进行了回顾性分析,用于骨切除术后的发作预防.
术后1至6天服用PER,并在7日和14日监测发作和副作用.
与接受 levetiracetam (LEV) 预防的 42 名患者进行比较.

主要成果:

在45名接受PER治疗的患者中,没有观察到早期发作 (7天内).
没有报告严重的药物不良反应 (血液学,肝脏,脏功能障碍).
常见的副作用包括昏昏欲睡 (31.1%),头 (6.7%) 和头痛 (6.7%),与LEV相比没有显著差异.

结论:

在脑瘤患者的早期发作预防中,外科术期间的perampanel (PER) 似乎是有效和安全的.
PER 显示出有利的安全性,可与 levetiracetam (LEV) 相比.
进一步的研究可能会支持PER作为在神经瘤学中进行外科手术期间发作预防的替代性AED.

关键词:

与脑瘤相关的发症早期的发作早期的发作质母细胞瘤 (glioblastoma) 是一个佩拉曼尼尔是一种制剂.副作用副作用副作用副作用

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