经过急性尾炎后结肠癌风险增加:一项全国性的基于人口的研究
Manon Viennet1, Solène Tapia2, Jonathan Cottenet2
1Department of Digestive Surgical Oncology, Dijon University Hospital, Dijon, France.
EClinicalMedicine
|September 8, 2023
概括
急性尾炎可能是结肠癌的信号,尤其是在诊断后的六个月内. 这项法国全国性的研究表明,需要增加尾炎患者的警和诊断工作.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 急性尾炎是一种常见的手术紧急情况.
- 结肠直肠癌是一个重大的公共卫生问题.
- 以前的研究表明,尾炎和结直肠癌风险之间存在潜在的联系.
研究的目的:
- 调查急性尾炎与随后结肠癌诊断之间的关联.
- 在全国范围内评估尾炎后结肠癌住院的频率.
- 为了评估不同年龄组之间的这种关联.
主要方法:
- 从2010年至2015年使用法国医院出院数据库 (PMSI).
- 包括18-59岁的急性尾炎患者,不包括已知结直肠癌风险因素的患者.
- 雇员倾向性得分匹配,将癌症发生与创伤匹配的对照组进行比较.
主要成果:
- 确定了230,349名尾炎患者和460,698名对照患者.
- 尾炎患者的结肠癌发病率明显较高,特别是在第一年 (5 vs 1 / 10,000).
- 风险在6个月内 (sHR=8.39) 和1年内 (sHR=4.67) 升高,右侧结肠癌显著增加,以及40岁以下的患者.
结论:
- 急性尾炎可能是结肠癌的潜在预警信号,表明逆因果关系.
- 观察到的风险增加,特别是在尾炎后的早期,需要考虑进行例行诊断工作.
- 这种关联在中年人和年轻人中显著,强调需要跨年龄组保持警.
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