全球脚病的出生率:一个系统的审查和元分析
Tracey Smythe1,2, Sara Rotenberg3, Chris Lavy4
1International Centre for Evidence in Disability, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, WC1E 7HT, UK.
EClinicalMedicine
|September 8, 2023
概括
在全球范围内,每年大约有176,476名儿童出生时患有脚. 这一系统性审查提供了第一个全球出生率估计,突出了低收入和中等收入国家之间的差异.
科学领域:
- 整形外科 整形外科 整形外科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- Clubfoot (先天性 talipes equinovarus) 是一个常见的出生缺陷.
- 据估计,低收入和中等收入国家 (LMICs) 的脚出生率在1000例出生中从0.5到2不等.
- 在此之前,缺乏全球估计脚出生率的估计.
研究的目的:
- 进行系统审查,以估计全球俱乐部脚的出生率.
- 为了确定全球脚发病率的区域差异.
- 为公共卫生策略和资源分配提供信息,用于脚管理.
主要方法:
- 2012年1月1日至2023年2月9日期间发表的研究的系统审查.
- 搜索了多个数据库,包括EMBASE,CINAHL,全球卫生,LILACS和Medline.
- 使用逆方差和随机效应模型计算聚合流行率;使用修改后的纽卡斯尔-太华尺度评估质量.
主要成果:
- 包括来自世界卫生组织五个区域36个国家的35项研究,分析了超过4400万例出生数据.
- 据估计,脚病的全球综合患病率为每1000例出生的1.18例 (95% CI:1.00-1.36).
- 在LMIC中发现了更高的患病率,特别是东南亚地区 (1.80) 和非洲地区 (1.31);据估计,全球每年有176,476名儿童出生时患有 clubfoot.
结论:
- 这项研究提供了第一个全面的全球估计脚出生率的普遍性.
- 在全球范围内存在相当大的脚负担,在LMICs中更高的比例.
- 研究结果强调,需要在资源有限的环境中改善获得有效的治疗和预防策略的机会.
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