相关实验视频
Updated: Jul 17, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
483
长期食道癌症风险和单次内镜查后不同的监测间隔:一个基于多中心人口的队列研究
He Li1,2, Changfa Xia1, Siyi He1
1Office of Cancer Screening, National Cancer Centre/ National Clinical Research Centre for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
EClinicalMedicine
|September 8, 2023
概括
一次内镜查显示,阴性发现的个体的食道癌 (EC) 风险较低,但轻度至中度发育不良患者的风险较高. 监测间隔可以根据这些长期结果进行调整.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 目前对温和中度发育不良和负面发现的内镜监测建议的证据有限.
- 这项研究评估了在一次内镜查后长期食道癌 (EC) 发病率和死亡率.
研究的目的:
- 在高风险个体进行一次性内镜查后,评估EC发病率和死亡率的长期风险.
- 为了比较EC风险在个人的负面发现,轻度形和中度形与一般人群.
主要方法:
- 一组42,827名高风险个人 (40-69岁) 经过负面发现,轻度或中度发育不良,被跟踪了平均10.62年.
- 卡普兰-梅尔分析了估计的累积EC发病率和死亡率. 考克斯回归和标准化比率 (SIR/SMR) 将不同组和一般人群之间的风险进行了比较.
主要成果:
- 10年累计EC发病率为0.45% (负),2.39% (轻度发育不良) 和8.90% (中度发育不良).
- 10年累积EC死亡率为0.23% (负),0.96% (轻度发育不良) 和2.50% (中度发育不良).
- 与负面发现相比,中度发育不良显示出EC发病率风险增加了13.18倍 (HR:13.18;95%CI:8.78-19.76).
结论:
- 内镜检查结果阴性的人在查后的10.62年内,EC风险低于一般人群.
- 轻度中度发育不良显著增加了EC风险,支持3年监测间隔.
- 对于内镜检查结果阴性的人来说,10年监测间隔可能是合适的.
相关概念视频
Barrett Esophagus-I: Introduction
122
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
122
Esophageal Strictures-I: Introduction
137
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
137
Barrett Esophagus-II: Clinical Manifestations and Management
191
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
191
Endoscopic Procedures I: Esophagogastroduodenoscopy
157
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
157
Esophageal Strictures-II: Clinical Features and Management
102
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
102
Endoscopic Procedures III: Video Capsule Endoscopy
186
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
186

