在中风后性患者中使用肉毒毒素:来自法国的全国性回顾性研究
Jonathan Levy1,2, Pierre Karam3, Anne Forestier4
1Department of Physical and Rehabilitation Medicine, Raymond-Poincaré Teaching Hospital, AP-HP, Université Paris-Saclay, Garches, France.
Frontiers in neurology
|September 8, 2023
概括
建议对性进行A型玻尿素毒素 (BoNT-A) 注射,但法国数据显示使用不足最佳. 治疗启动和再给药率较低,特别是在中风后性患者中.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 肌肉内毒素A型 (BoNT-A) 是由于中枢神经系统 (CNS) 病变引起的性的一线治疗方法.
- 性管理通常需要每3-4个月注射一次BoNT-A.
- 法国的一项全国性研究分析了2014年至2020年间BoNT-A用于性.
研究的目的:
- 描述BoNT-A在法国治疗性的现实应用.
- 评估对BoNT-A.的推治疗频率的遵守情况.
- 识别性护理途径中的潜在缺口.
主要方法:
- 使用法国国家医院出院数据库 (PMSI) 进行的回顾性队列研究.
- 对接受BoNT-A注射的138,481名患者 (2014-2020年) 的分析.
- 对318,025名中风幸存者的性护理途径的检查 (2014-2016年队列,随后到2020年).
主要成果:
- 超过62%的BoNT-A治疗患者患有中枢神经系统病变.
- 针对中枢神经系统病变的BoNT-A注射数量每年增加到2019年,然后在2020年略有下降.
- 只有2.3%的中风幸存者接受了BoNT-A,0.8%接受了推的再给药频率.
结论:
- 法国对BoNT-A治疗性治疗指南的实施不足于最佳水平.
- 观察到BoNT-A启动和再给药率较低,特别是在中风后的性中.
- 需要进一步的研究来改善性管理和护理途径.
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