口服微生态剂对结直肠癌外科术期间指标的干预作用:一个元分析
Xueyan Wang1, Lijun Pan2, Feiqing Wang3
1The First College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Frontiers in oncology
|September 8, 2023
概括
微生态剂改善肠道健康,并减少接受手术的结肠直肠癌患者的不良事件. 这种方法增强了免疫功能和临床结果,提供了一个有前途的治疗策略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 患者的外科手术期间管理需要策略来缓解并发症和改善结果.
- 肠道失生症是CRC患者常见的问题,可能会加剧与治疗相关的不良反应.
- 微生态剂提供了一个潜在的途径来调节肠道微生物组,并支持患者的康复.
研究的目的:
- 评估微生态剂在接受结直肠癌术前治疗的患者中的疗效.
- 评估这些药物对肠道菌群,炎症标志物,免疫功能和临床结果的影响.
主要方法:
- 一项对38项随机对照试验 (RCT) 的系统综述和元分析,涉及3534名患者 (微生态剂组1765名,对照组1769名).
- 从七个主要的电子数据库 (PubMed,Embase,WOS等) 中确定了研究. 发表于2000年至2023年2月期间.
- 数据分析使用Review Manager 5.4和R 4.2.2软件进行.
主要成果:
- 微生态剂显著改善了肠道菌群,增加了诸如*Lactobacillus*和*Bifidobacterium*这样的有益细菌,同时减少了有害的*Escherichia coli*.
- 这些药物通过降低内毒素,DAO和血D-乳酸盐水平来保护肠粘膜屏障功能.
- 观察到炎症标志物 (IL-6,CRP) 的显著减少和免疫功能 (CD4+,CD4+/CD8+,IgG) 的改善.
- 短期临床疗效得到加强,客观响应率 (ORR) 和疾病控制率 (DCR) 得到改善.
- 药物不良反应,包括感染和胃肠道不适,减少了.
结论:
- 微生态剂有效地解决了手术前CRC患者的肠道调节障碍.
- 它们显然可以减少药物不良反应,如感染和胃肠道不适.
- 这些药物增强免疫功能,保护肠道屏障,改善短期临床结果.
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