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Updated: Jul 17, 2025

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
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A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors

Published on: August 17, 2019

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对AKR1B10和阿尔多减少酶 (AR) 的抑制选择性:从分子动力学模拟和自由能量计算中的洞察力

Ping Lin1,2, Yuzhen Niu1,3

  • 1Weifang University of Science and Technology Weifang 262700 China linping07@mails.ucas.ac.cn niuyzh12@lzu.edu.cn.

RSC advances
|September 8, 2023
PubMed
概括

在癌症中准过度表达的AKR1B10蛋白质是具有挑战性的,因为它与AR的相似性. 这项研究揭示了设计选择性AKR1B10抑制剂的关键相互作用,重点关注范德瓦尔斯,静电和键.

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