人类乳头瘤病毒感染在异常巴氏涂抹中的患病率
Jaya Mishra1, Sweety Kalantri1, Vandana Raphael1
1Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
CytoJournal
|September 8, 2023
概括
这项研究发现,高风险的人类乳头瘤病毒 (HPV) 感染的患病率随着宫病变的严重程度而增加. 与未确定意义的非典型状细胞 (ASCUS) 相比,在状细胞内皮质病变中,HPV阳性显著更高.
科学领域:
- 妇科瘤学 妇科瘤学
- 病毒学 病毒学
- 细胞病理学 细胞病理学
背景情况:
- 宫癌查依赖于检测细胞学异常.
- 人类乳头瘤病毒 (HPV) 是导致子宫癌的主要原因.
- 了解异常涂抹中的HPV患病率对于风险分层至关重要.
研究的目的:
- 在异常的宫巴氏涂抹中确定高风险HPV (HR-HPV) 感染的患病率.
- 为了将细胞学发现与HR-HPV检测率相关联.
- 评估病变严重程度和HPV阳性之间的关系.
主要方法:
- 1788名30岁以上妇女的宫巴氏涂片被使用基于液体的细胞学分析.
- 聚合酶链反应 (PCR) 用于对异常涂抹进行HR-HPV测试.
- 当可用时,进行了组织病理相关性.
主要成果:
- 总体而言,7.60%的涂抹显示出异常,ASCUS是最常见的.
- 在所有异常涂抹的68.83%中检测到HR-HPV.
- 随着病变严重程度的增加,HPV阳性增加了:45%在ASCUS中,73.07%在LSIL中,86.67%在HSIL中,83.34%在恶性病例中.
结论:
- HR-HPV的患病率与宫细胞学异常的严重程度有显著的相关性.
- 与ASCUS相比,状内皮层病变的HPV阳性率高出四倍.
- 这些发现支持HPV测试在管理异常宫细胞学的作用.
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