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电治疗对大脑结构的长期影响在严重抑郁症中

Tiana Borgers¹, Verena Enneking¹, Melissa Klug¹

¹Institute for Translational Psychiatry, University of Münster, Albert-Schweitzer-Campus 1, Building A9a, 48149 Münster, Germany.

Psychological medicine

|September 8, 2023

概括

电疗法 (ECT) 在严重抑郁症 (MDD) 患者中暂时增加灰质体积 (GMV). 这些GMV变化是短暂的,与抗抑郁药效应无关,长期结果与体积减少相关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
放射学放射学是一门学科.

背景情况:

使用MRI进行的大型抑郁症 (MDD) 研究经常显示,在电疗法 (ECT) 后,灰质量 (GMV) 暂时增加.
在MDD患者中,这些ECT诱导的GMV变化的长期稳定性仍未得到研究.
本研究研究了长期的GMV变化及其在ECT后的临床相关性.

研究的目的:

为了研究灰质体积 (GMV) 变化的长期稳定性,在大型抑郁症 (MDD) 患者的电疗法 (ECT) 后在2年内.
探索这些长期的GMV变化与ECT治疗的MDD患者的临床结果之间的关联.

主要方法:

一项非随机的纵向研究,涉及17名接受ECT的MDD患者,在基线 (t0),ECT后 (t1) 和2年后 (t2) 进行结构性MRI扫描.
包括一个健康的对照组 (n=21) 和一个MDD非ECT对照组 (n=33),也在同一时间间隔中扫描了三次.
分析采用了3个组) ×3个时间) 的ANOVA和与临床结果变量的相关性分析.

主要成果:

由于ECT组的GMV从t0增加到t1并随后从t1降低到t2,特别是在边缘区域,观察到显著的组 × 时间相互作用 (p < 0.001).
在任何对照组中都没有发现显著的时间效应.
短期GMV增加 (t0-t1) 与症状增加相关,而长期GMV减少 (t1-t2) 与较差的长期抑郁结果相关 (所有p ≤0.049).

结论:

ECT诱导的GMV增加是暂时的,治疗后2年观察到显著下降.
短期的GMV增加似乎不会调解ECT的抗抑郁作用.
更大的长期GMV下降与较差的长期抑郁结果有关,这表明疾病进展和大脑结构变化之间的相互作用.

关键词:

抑郁症抑郁症抑郁症抑郁症电疗法是一种电疗法.影像成像技术影像成像技术在纵向的长度上.治疗反应治疗反应的治疗.

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