在SARS-Cov-2感染后的精神病学后果:澳大利亚纵向队列中的轨迹,预测因素和关联
Seetal Dodd1,2,3, Mohammedreza Mohebbi1,4, Josie O'Donohue1
1Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.
Acta neuropsychiatrica
|September 8, 2023
概括
长期COVID,而不是疾病严重程度,强烈预测SARS-CoV-2感染后的神经精神症状. 这项为期12个月的研究强调长期COVID是感染后心理健康结果的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 已确认SARS-CoV-2感染与精神症状之间的联系,但需要进一步调查.
- 神经精神病学的后果是已知的各种感染的并发症,这使得它们对SARS-CoV-2具有可信性.
研究的目的:
- 在12个月内调查SARS-CoV-2感染和神经精神症状之间的纵向关系.
- 探索心理健康结果,长期COVID状态,疾病严重程度和炎症生物标志物之间的关联.
主要方法:
- 在144名确诊感染SARS-CoV-2的个体进行了为期12个月的纵向研究.
- 数据收集包括医疗和神经精神评估,生物标本和验证问卷 (SPHERE,DIMI,EQ-5D-5L,疲劳VAS) 在6次访问中.
- 用通用估计方程来分析心理健康措施,疾病参数和炎症生物标志物之间的关联.
主要成果:
- 在炎症生物标志物和心理健康措施之间发现了显著的关联.
- 在心理健康结果和长期COVID状态之间观察到强烈的反向关联.
- 在心理健康结果和急性COVID-19疾病的严重程度之间没有发现显著的关联.
结论:
- 长期COVID状态似乎是SARS-CoV-2感染后个体神经精神病症状的最重要的预测因素.
- 这些发现强调了在SARS-CoV-2感染后对心理健康挑战的管理中考虑长期COVID的重要性.
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