在结核病和人体免疫缺陷病毒复杂的前阴中对炎症细胞和免疫检查点的审查
Wendy N Phoswa1, Olive P Khaliq2, Simeon Eche3
1Department of Life and Consumer Sciences, Science Campus, University of South Africa (UNISA), Private Bag X 6, Florida, Roodepoort 1710, South Africa.
International journal of environmental research and public health
|September 8, 2023
概括
本综述研究了与结核病 (TB) 和艾滋病毒相关的先兆子 (PE) 中的炎症细胞和免疫检查点. 这些途径的失调会增加感染孕妇的PE风险,这表明治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 产科 产科 产科 产科 产科
- 传染性疾病 传染性疾病
背景情况:
- 在患有结核病 (TB) 或人类免疫缺陷病毒 (HIV) 的孕妇中,孕前 (PE) 的风险较高.
- 炎症体和免疫检查点在免疫调节中至关重要,并与各种炎症状况有关.
研究的目的:
- 审查结核病和艾滋病毒患者在孕前 (PE) 中的炎症细胞和免疫检查点的调节.
- 探索炎症细胞/免疫检查点调节失调与结核/艾滋病毒感染怀孕中乳腺发育风险增加之间的联系.
- 确定潜在的治疗策略,针对这些途径来预防和管理PE.
主要方法:
- 对研究炎症体 (NLRP3,NEK7,AIM2) 和免疫检查点 (TIGIT,PD-1,TIM-3,LAG-3) 的文献综述.
- 对结核病和艾滋病毒感染中的免疫失调数据的分析.
- 检查这些免疫因素与子宫前发育之间的关联.
主要成果:
- 炎症细胞 (NLRP3,NEK7,AIM2) 和免疫检查点 (TIGIT,PD-1,TIM-3,LAG-3) 在结核病和艾滋病毒患者中显示出调节障碍.
- 这种失调也观察到在先兆子怀孕.
- 患有结核病或艾滋病毒的孕妇表现出更高的PE发病率,与这些免疫变化有关.
结论:
- 不调节的炎症细胞和免疫检查点有助于增加结核病和艾滋病毒感染的孕妇患子宫前的风险.
- 准炎酶和免疫检查点为开发新型抗炎疗法提供了一个有希望的途径.
- 旨在调节这些途径的干预措施可以帮助在不同的患者群体中预防和管理PE,包括那些同时患有结核病或艾滋病毒感染的人.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒免疫检查点是免疫检查点.炎症酶体 (inflammasomes) 是一种炎症酶体.这是一种炎症炎症炎症炎症.孕产妇产前炎症 (pre-eclampsia) 是一个严重的疾病.结核病是一种肺结核病.更多相关视频
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