相关实验视频
Updated: Jul 17, 2025

12:31
An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
11.5K
整合素和雄激素在乳腺癌中的作用
Chung-Che Tsai1,2, Yu-Chen S H Yang3, Yi-Fong Chen1
1Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Cells
|September 8, 2023
概括
雄激素可以通过整合素αvβ3和编程死亡配体1 (PD-L1) 刺激乳腺癌的生长. 这项研究使用分子建模来探索这些雄激素-整合素相互作用及其在癌症进展中的作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 雄激素调节男性生理和癌症扩散,在乳腺癌中发挥复杂的作用.
- 虽然雄激素可以对抗雌激素的作用,但它们也可以刺激ER阳性和ER阴性乳腺癌细胞的生长.
- 雄激素诱导的癌症生长和转移与整合素有关,特别是整合素αvβ3,以及编程死亡配体1 (PD-L1).
研究的目的:
- 阐明癌细胞中与整合素αvβ3相互作用的基因分子机制.
- 研究雄激素在调节PD-L1表达中的作用及其对癌症生长的影响.
- 提供对雄激素在乳腺癌扩散中的双重作用的机制性理解.
主要方法:
- 用分子建模来模拟和分析雄激素和整合素αvβ3.3之间的潜在相互作用.
- 文献综述和数据分析被用来评估雄激素,整合素和PD-L1在癌症中的已知作用.
主要成果:
- 分子建模提供了对雄激素和整合素αvβ3.3之间潜在的结合部位和相互作用的见解.
- 该研究探讨了影响PD-L1表达的雄激素调节机制及其下游效应.
- 证据表明一个复杂的相互作用,其中雄激素可以通过整合素通路促进癌细胞的生长.
结论:
- 雄激素与整合素αvβ3的相互作用是促进癌细胞生长和潜在的转移的关键机制.
- 了解这些相互作用对于开发针对雄激素敏感癌症的向疗法至关重要.
- 需要进一步的研究,以充分界定所涉及的信号通路及其治疗影响.
相关概念视频
Activation of Integrins
3.5K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
3.5K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Intracellular Signaling Affects Focal Adhesions
2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.7K
Integrins
4.0K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
4.0K
Internal Receptors
70.3K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
70.3K
Intracellular Hormone Receptors
55.5K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
55.5K

