基因组景观和3D文化功能测试的结合将肉瘤表现型与向和免疫疗法的桥梁
Filomena de Nigris1, Concetta Meo1, Wulf Palinski2
1Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Cells
|September 8, 2023
概括
仅靠基因组分析对瘤治疗是不够的. 个性化的3D瘤模型提供了一个有前途的功能测试,可以预测患者的反应,并为罕见癌症提供先进的精准医学.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 生物技术是生物技术.
背景情况:
- 基因组分析已经改善了肉瘤治疗,但由于瘤的稀有性和异质性,在预测治疗反应方面存在局限性.
- 目前的基因组方法本身不足以指导有效的肉瘤治疗策略.
研究的目的:
- 审查目前针对肉瘤的向治疗方法.
- 讨论个性化的3D瘤模型作为功能测试来预测治疗反应的潜力.
- 探索3D模型如何在肉瘤治疗中增强精密医学.
主要方法:
- 目前针对肉瘤的向治疗方法的概述.
- 使用个性化的3D瘤模型进行功能性测试的讨论.
- 分析3D模型重复分子路径和瘤微环境的能力.
主要成果:
- 基因组变化在肉瘤中至关重要,但不能完全预测治疗结果.
- 个性化的3D瘤模型在功能性药物查中显示出希望.
- 3D模型可以通过模仿瘤生物学和微环境来预测患者的反应.
结论:
- 个性化的3D瘤模型为肉瘤治疗的基因组查提供了一种补充方法.
- 这些模型可以指导精准医学,当基因组数据不足时.
- 对于临床实施,3D培养试验的进一步标准化是必要的.
关键词:
3D模型是3D模型.测试试验 测试试验 测试试验临床试验临床试验临床试验临床试验临床试验一个解释的解释者.基因组概况的基因组概况免疫疗法 免疫疗法器官在芯片上的器官有机体向治疗的目标疗法肉瘤 肉瘤是一种肉瘤.更多相关视频
07:48Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
11.4K
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
7.3K
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K