可激活的I型光敏化剂与灭光敏化剂光动力学治疗前后光动力学治疗
Jianwu Tian1, Bowen Li1, Fu Zhang2
1Department of Chemical and Biomolecular Engineering, National University of Singapore, 5 A Engineering Drive 1, Singapore, 117411, Singapore.
Angewandte Chemie (International ed. in English)
|September 8, 2023
概括
这项研究引入了一种新型的光敏感剂,它只在缺氧瘤中活跃,在光动力学治疗 (PDT) 之前和之后最大限度地减少毒性. 这种按需激活可以提高癌症治疗的安全性和治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 摄影化学的使用.
- 纳米医学是一种纳米医学.
背景情况:
- 光动力疗法 (PDT) 受到光敏剂 (PS) 光毒性和瘤缺氧的限制.
- 现有的解决方案解决了PDT前的毒性或缺氧,但不是PDT后的效应.
- 解决所有局限性的单一设计仍然难以捉摸.
研究的目的:
- 开发一种可按需切换的光敏化剂.
- 为了创建一个PS与灭光敏化前和后PDT.
- 设计一个在低氧瘤微环境中特别激活的PS.
主要方法:
- 设计了一种对缺氧-正常氧循环反应的I型PS (TPFN-AzoCF3).
- 使用DSPE-PEG-2000将TPFN-AzoCF3制成纳米粒子 (NP).
- 在体外和体内评估NP激活和ROS生成.
主要成果:
- 在低氧瘤中,TPFN-AzoCF3NP显示有选择性的激活.
- 在低氧条件下,NP有效地产生I型ROS.
- 在PDT前或后的正常组织中观察到最小的毒性.
结论:
- 开发的可切换PS NPs为PDT提供按需激活.
- 这一策略通过减少非目标毒性来最大限度地减少副作用.
- 这种方法可以提高治疗效率,并为未来的PS设计铺平了道路.
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